Journals & Patents

Learning and Thinking.  Paper presented at an online meeting of the Society for Medicines Research, “The Reality of Artificial Intelligence in Drug Discovery”, 4th March 2021.

Hitesh Patel; Wolf-Dietrich Ihlenfeldt; Philip N. Judson; Yurii S. Moroz; Yuri Pevzner; Megan L. Peach; Victorien Delannée; Nadya I. Tarasova; Marc C. Nicklaus. SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules.  Scientific Data, 2020, 7, Article 384 (2020). https://www.nature.com/articles/s41597-020-00727-4.

Philip N. Judson; Wolf-Dietrich Ihlenfeldt; Hitesh Patel; Victorien Delannée; Nadya Tarasova; Marc C. Nicklaus.  Adapting CHMTRN (CHeMistry TRaNslator) for a New Use.  DOI: 10.1021/acs.jcim.0c00448.

Chris Barber; Thierry Hanser; Philip Judson; Richard Williams.  Distinguishing between expert and statistical systems for application under ICH M7.  Reg. Toxicol. and Pharmacol., 2017, 84, 124-130.

Fidele Ntie-Kang; Conrad Veranso Simoben; Berin Karaman; Valery Fuh Ngwa; Philip Neville Judson; Wolfgang Sippl; Meva’a Mbaze.  Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from african medicinal plants. Drug Design, Development and Therapy, 2016, 10, 2137–2154.

Philip N. Judson; Anthony Long; Ernest Murray; Mukesh Patel.  Assessing confidence in predictions using veracity and utility – a case study on the prediction of mammalian metabolism by Meteor Nexus.  Molecular Informatics, 2015, 34(5), 284-291.  http://dx.doi.org/10.1002/minf.201400184.

Philip N. Judson; Christopher Barber; Steven J. Canipa; Géraldine Poignant; Richard Williams.  Establishing Good Computer Modelling Practice (GCMP) in the Prediction of Chemical Toxicity.  Molecular Informatics, 2015, 34 (5), 276–283.

Richard Sherhod; Philip N. Judson; Thierry Hanser; Jonathan D. Vessey; Samuel J. Webb; Valerie J. Gillet.  Emerging Pattern Mining To Aid Toxicological Knowledge Discovery.  J. Chem. Inf. Model., 2014, 54 (7), 1864–1879.

Lydia L. Lifongo; Conrad V. Simoben, Fidele Ntie-Kang F, Smith B Babiaka, Philip N.Judson. A Bioactivity versus Ethnobotanical Survey of Medicinal Plants from Nigeria, West Africa. Nat Prod. Bioprospect., 2014, 4, 1-19.

Fidele Ntie-Kang; Lydia L. Lifongo; Philip N. Judson; Wolfgang Sippl; Simon M. N. Efange.  How “drug-like” are naturally occurring anti-cancer compounds?  Journal of Molecular Modeling, 2014, 20, 2069.

Mohammed Ali: Mukesh Patel; David Wilkinson; Philip Judson; Kevin Cross. ToxML, a data exchange standard with content controlled vocabulary used to build better (Q)SAR models.  SAR and QSAR in Environmental Research, 2013, 24(6), 429-438.

Richard Sherhod; Valerie J. Gillet; Thierry Hanser; Philip N. Judson; Jonathan D. Vessey.  Toxicological knowledge discovery by mining emerging patterns from toxicity data.  Journal of Cheminformatics, 2013, 5(Suppl 1):O9.

Fidele Ntie-Kang; James Mbah; Lydia Lifongo; Luc Owono Owono; Eugene Megnassan; Luc Meva'a Mbaze; Philip Judson; Wolfgang Sippl; Simon Efange. Assessing the pharmacokinetic profile of the CamMedNP natural products database: an in silico approach.  Organic and Medicinal Chemistry Letters, 2013, 3:10.

Fidele Ntie-Kang; Lydia L. Lifongo; James A. Mbah; Luc C. Owono Owono; Eugene Megnassan; Luc Meva’a Mbaze; Philip N. Judson; Wolfgang Sippl; Simon M. N. Efange.  In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin.  In Silico Pharmacology, 2013, 1:12.

Philip N. Judson; Susanne A. Stalford; Jonathan Vessey.  Assessing Confidence in Predictions Made by Knowledge-Based Systems.  Toxicology Research, 2013, 2(1), 70 – 79.

Richard Sherhod; Valerie J. Gillet; Philip N. Judson; Jonathan D. Vessey. Automating Knowledge Discovery for Toxicity Prediction Using Jumping Emerging Pattern Mining.  Journal of Chemical Information and Modelling, 2012, 52(11), 3074-3087.

Hardy, B.; Apic, G.; Carthew, P.; Clark, D.; Cook, D.; Dix, I.; Escher, S.; Hastings, J.; Heard, D. J.; Jeliazkova, N.; Judson, P.; Matis-Mitchell, S.; Mitic, D.; Myatt, G.; Shah, I.; Spjuth, O.; Toheremenskaia, O.; Toldo, L. Toxicology Ontology Perspectives.  ALTEX, 2012, 29, 139-156.

Hardy, B.; Apic, G.; Carthew, P.; Clark, D.; Cook, D.; Dix, I.; Escher, S.; Hastings, J.; Heard, D. J.; Jeliazkova, N.; Judson, P.; Matis-Mitchell, S.; Mitic, D.; Myatt, G.; Shah, I.; Spjuth, O.; Toheremenskaia, O.; Toldo, L. Food for Thought ... A Toxicology Ontology Roadmap.  ALTEX, 2012, 29, 129-137.

Judson, Philip.  A Chemical Bioactivity Information Centre for Africa.  Paper presented at the first meeting of the West African Society of Toxicology, “Toxicological and Environmental Health Issues in Sub-Saharan Africa: A Neglected Priority Area”, Benin City, Nigeria, 7th-10th February 2012.

Judson, Philip.  Introduction to Predictive Toxicology.  Paper presented at the first meeting of the West African Society of Toxicology, “Toxicological and Environmental Health Issues in Sub-Saharan Africa: A Neglected Priority Area”, Benin City, Nigeria, 7th-10th February 2012.

Sherhod, Richard; Gillet, Val; Hanser, Thierry; Vessey, Jonathan; Judson, Philip. Development of a Software Tool to Mine Emerging Structural Patterns for Identification of Toxicophores.  Poster presented at the UK-QSAR and Chemoinformatics Group Autumn Meeting, Cambridge, England, 3rd November 2011.

Ellison, C. M.; Sherhod, R.; Cronin, M. T.; Enoch. S. J., Madden, J. C.; Judson, P. N. Assessment of Methods to Define the Applicability Domain of Structural Alert Models.  Journal of Chemical Information and Modelling, 2011, 51, 975-985.

Alkarouri, Muhammad; Sherhod, Richard; Gillet, Val; Judson, Philip; Richmond, Nicola. J.  A Comparison of Emerging Pattern Mining and Formal Concept Analysis.  Poster presented at the 5th Joint Sheffield Conference on Chemoinformatics, Sheffield, England, 13th-15th July 2010.

Sherhod, Richard; Gillet, Val; Judson, Philip.  Mining of Emerging Structural Patterns for Association with Toxicological Activity.  Poster presented at the 5th Joint Sheffield Conference on Chemoinformatics, Sheffield, England, 13th-15th July 2010.

Judson, Philip Neville.  Towards Establishing Good Practice in the Use of Computer Prediction.  Quality Assurance Journal, 2010, 12, 120-125.

Ellison, C. M.; Madden, J. C.; Judson, P. N.; Cronin, M. T. D.  Application of In Silico Tools in a Weight of Evidence Approach to Aid Toxicological Assessment.  Poster presented at 18th European Symposium on Quantitative Structure Activity Relationships, Rhodes, Greece, 19th-24th September 2010.

Ellison, Claire M.; Madden, Judith C.; Judson, Philip N.; Cronin, Mark T.D.  Using In Silico Tools in a Weight of Evidence Approach to Aid Toxicological Assessment Via Integrated Testing Strategies.  Molecular Informatics, 2010, 29, 97 – 110.

Ellison, Claire M.; Enoch, Steven J.; Cronin, Mark T.D.; Madden, Judith C.; Judson, Philip N.  Definition of the Applicability Domains of Knowledge-Based Predictive Toxicology Expert Systems by Using a Structural Fragment-Based Approach. ATLA, 2009, 37(5), 533-545.

Ellison, C. M.; Cronin, M. T. D.; Madden, J.C.; Judson, P. N. Optimising in Silico Models to Facilitate a Reduction in In Vivo Testing.  Poster presented at 7th World Congress on Alternatives and Animal Use in the Life Sciences, Rome, Italy, 30th August – 3rd September 2009.

Judson, Philip N.  Using (Q)SAR for REACH and GHS Compliance.  Paper presented at the Fall Meeting of the Society for Chemical Hazard Communication, Arlington, Virginia, USA, 23rd-24th September 2008.

Patel, M. L.; Hobbs, M. D.; Judson, P. N.; Ott, M. A.; Ulyatt, M.; Vessey, J. D.  Consensus Modelling of Biodegradation Pathways.  Poster presented at 8th International Conference on Chemical Structures, Noordwijkerhout, The Netherlands, 1st-5th June 2008.

Judson, Philip N.  Sharing Knowledge to Avoid Duplication.  Paper presented at the 6th World Congress on Alternatives and Animal Use in the Life Sciences – Tokyo, Japan 21st-25th August 2007.

Covey-Crump, Elizabeth M.; MacDonald, Scott; Naven, Russell T.; Judson, Philip. N.; Marchant, Carol A.  Practical Approaches to Sharing Toxicity Data.  Poster presented at the 6th World Congress on Alternatives and Animal Use in the Life Sciences – Tokyo, Japan 21st-25th August 2007.

Stei, P.; Smith, D.; Pfister, R.; Sparrow, S.; Rabemampianina, Y.; Stephan-Gueldner, M.; Stark, C.; von Landenberg, F.; Lammens, L.; Paarup, A. M.; Phillips, B.; Combes, R.; Briggs, K.; Judson, P.  The Excipient Database: an Initiative of European Pharmaceutical Companies and Lhasa Limited to Refine and Avoid Duplication of Animal Studies. Poster presented at the FELASA-ICLAS Joint Meeting – Como, Italy, June 11th-14th 2007.

Judson, Philip.  Computer Prediction of the Likelihood of Biodegradation Pathways.  Paper presented at the 12th International Workshop on Quantitative Structure-Activity Relationships in Environmental Toxicology, Lyon, 8th-12th May 2006.

Judson, Philip.  Validity of SAR.  Paper presented at a seminar, “Application of Structure-Activity Relationships to Chemical Safety”, Chemical Hazards Communication Society, Nottingham, 1st March 2006.

Judson, Philip.  Using Computer Knowledge-Based Systems to Predict Metabolism and Toxicity.  Paper presented at the 2005 WHTS 3rd Annual Congress of International Drug Discovery Science and Technology, Shanghai, 28th-30th October 2005.

Testa, Bernard; Balmat, Anne-Loyse; Long, Anthony; Judson, Philip. Predicting Drug Metabolism – an Evaluation of the Expert System METEOR. Chemistry and Biodiversity, 2005, 2, 872-885.

Cooke, P. A.; Doerrer N. G.; Hanzlik, R. P.; Hartmann, A.; Judson, P. N.; Müller, L.; Steger-Hartmann, T.; Rothfuss, A.; Thomas, K.; Vessey, J. D.; Zeiger, E. Towards the Creation of an International Toxicology Information Centre.  Toxicology, 2005, 213, 117-128.

Judson, P. N.  Models for Computer Reasoning Under Uncertainty.  Paper presented at the Skolnik Award Session in honour of Professor A. P. Johnson during a national meeting of the American Chemical Society, Philadelphia, August 2004.

Hayward, Julian; Judson, Philip; Vessey, Jonathan.  Uses and Potential Uses of Reasoning in Chemoinformatics: Could it Help You?  Poster presented at the 7th International Conference on Chemical Structures, Noordwijkerhout, 5th-9th June 2005.

Judson, P. N.  EU Proposals for an Internet-based Decision Support System for REACH in Europe.  Paper presented at the ADMET 2 Conference, San Diego, 9th-11th January 2005.

Judson, P. N.  The Role of Predictive ADMET in Drug Design – Is it Adding Value?  Paper presented at IBC Conference on Advances in Drug Design, London, 28-29th June 2004.

Judson, P. N.; Vessey, J. D.  A Comprehensive Approach to Argumentation. Journal of Chemical Information and Computer Science, 2003,  43, 1356-1363.

Judson, P. N.; Marchant, C. A.; Vessey, J. D.  Using Argumentation for Absolute Reasoning about the Potential Toxicity of Chemicals.  Journal of Chemical Information and Computer Science, 2003,  43, 1364-1370.

Button, W. G.; Judson, P. N.; Long, A.; Vessey, J. D. Using Absolute and Relative Reasoning in the Prediction of the Potential Metabolism of Xenobiotics.  Journal of Chemical Information and Computer Science, 2003,  43, 1371-1377.

Judson, P. N.  Prediction of Toxicity Using DEREK for Windows.  Journal of Toxicological Sciences, 27, 278, 2002. Paper presented at the annual meeting of the Japanese Chemical Society, Nagoya, 18-20th June 2002.

Judson, Philip.  Predicting Toxicity and Metabolism by Computer.  Paper presented at the World Chemistry Congress, Brisbane, Australia, 1st-6th July 2001.

Judson, P. N.  A Consortium Approach to Building a Toxicology Database from Proprietary Compounds. Paper presented at two symposia entitled “INFOTECHpharma 2000”, organised by IBC Global Conferences Ltd, London, 26-28th January 2000, and by IBC USA (Conferences) Inc, Philadelphia, 21st-23rd June 2000.

Greene, N.; Judson, P. N.; Langowski, J. J.; Marchant, C. A.  Knowledge-Based Expert Systems for Toxicity and Metabolism Prediction: DEREK, StAR and METEOR.  SAR and QSAR in Environmental Research, 1999, 10, 299-314.

Dearden, John C.; Barratt, Martin D.; Benigni, Romualdo; Bristol, Douglas W.; Combes, Robert D.; Cronin, Mark T. D.; Judson, Philip N.; Payne, Martin P.;. Richard, Ann M.; Tichy, Milon; Worth, Andrew P.; Yourick, Jeffrey J.  The Development and Validation of Expert Systems for Predicting Toxicity.  ATLA, 1997, 25, 223-252.

Tonnelier, C. A. G.; Fox, J.; Judson, P.; Krause, P.; Pappas, N.; Patel, M. Representation of Chemical Structures in Knowledge-Based Systems: the StAR System.  Journal of Chemical Information and Computer Science, 1997, 37, 117-123.

Langowski, Jan. J.; Judson, Philip N.; Patel, Mukesh; Tonnelier, Christian A. G.  StAR. A Knowledge-Based Computer System for Carcinogenic Risk Assessment. In “Animal Alternatives, Welfare and Ethics. Developments in Animal and Veterinary Sciences”, Vol. 27, eds. LFM Van Zutphen and M. Balls, Elsevier Science, 1997, pp. 747-752.

Judson, Philip N.  Accessing Knowledge about Chemical Synthesis by Computer.  Chimica Oggi, 14(9), 21-24, 1996.  Paper presented at the BACS Symposium, Chemspec Europe 95, Essen, Germany, 20-21st June 1995.

Judson, Philip N.; Combes, Robert D.  Artificial Intelligence Systems for Predicting Toxicity.  Pesticide Outlook, 1996, 7(4), 11-15.

Ridings, James E.; Barratt, Martin D.; Cary, Richard; Earnshaw, Christopher G.; Eggington, Elaine; Ellis, Martin K.; Judson, Philip N.; Langowski, Jan. J.; Marchant, Carol A.; Payne, Martin P.; Watson, William P.; Yih, T. D.  Computer Prediction of Possible Toxic Action from Chemical Structure: an Update on the DEREK System.  Toxicology, 1996, 106, 267-279.

Judson, P. N.; Krause, P.; Fox, J.  Using New Reasoning Technology in Chemical Information Systems.  Paper presented at XIth International Conference on Computers in Chemical Research and Education, Paris, 17th-21st July 1995.  Journal of Chemical Information and Computer Science, 1996, 36, 621-624.

Judson, Philip.  The Dialectic of Risk: First StAR Project Demonstrator Arrives. In “AI Watch”, December 1995, ed. Goodall, A., AI Intelligence, Oxford, 1995.

Combes, Robert D.; Judson, Philip.  The Use of Artificial Intelligence Systems for Predicting Toxicity.  Pesticide Science, 1995, 45, 179-194.

Krause, Paul; Fox, John; Judson, Philip.  An Argumentation Based Approach to Risk Assessment.  IMA Journal of Mathematics Applied in Business and Industry, 1993/4, 5, 249-263.

Judson, Philip N. Rule Induction for Systems Predicting Biological Activity. Journal of Chemical Information and Computer Science, 1994, 34, 148-53.  Paper presented at the Third International Conference on Chemical Structures, Noordwijkerhout, June 1993.

Judson, Philip N.  Structural Similarity Searching Using Descriptors Developed for Structure Activity Relationship Studies.  Journal of Chemical Information and Computer Science, 1992, 32, 657-663.  Paper presented at the Third Beilstein Workshop, Bolzano, May 1992.

Judson, Philip N.  QSAR and Expert Systems in the Prediction of Biological Activity.  Pesticide Science, 1992, 36, 155-160.

Johnson, A. Peter; Marshall, Chris; Judson, Philip N.  Starting Material Oriented Retrosynthetic Analysis in the LHASA Program.  Journal of Chemical Information and Computer Science, 1992, 32, 411-417.

Hannaby, Malcolm; Judson, Philip; Warren, Stuart.  Stereo- and Regio- Chemical Control in Phenylthio Migration Around Rings of Sizes 5-15.  Journal of the Chemical Society, Perkin Transactions I, 20, 1992, 2609-2614.

Johnson, A. Peter; Marshall, Chris; Judson, Philip N.  Some Recent Progress in the Development of the LHASA Computer Program for Synthesis Design.  Recueil des Travaux Chimiques des Pays-Bas, 1992, 111, 310-316.

Judson, Philip N.  Recent Developments in Reaction Indexing.  Proceedings of the Montreux 1990 International Chemical Information Conference, 24-26th September 1990, 13-16.

Judson, Philip N.  Industrial and Academic Researchers Open Second Decade of Collaboration on LHASA Program.  Chemical Design Automation News, 1990, 5, 6-7.

Sanderson, Derek M.; Earnshaw, Christopher G.; [Judson, Philip N]. Computer Prediction of Possible Toxic Action from Chemical Structure; the DEREK System.  Human and Experimental Toxicology., 1991, 10, 261-273.  [P. N. Judson was omitted from the author list in the original paper.  An erratum was issued subsequently by the publisher]

Judson, Philip N.  The Use of Expert Systems for Detecting Potential Toxicity.  Paper presented at the Autumn meeting of the British Toxicological Society, 20th-22nd September 1989.

Hopkinson, Glen A.; Judson, Philip N.  Artificial Intelligence in Information Systems.  Chemistry in Britain, 1989, 25, 1122-1124.

Judson, Philip N.; Rowson, Graham P.  Understanding the Site of Action of Photosystem II Inhibitors.  Pesticide Science, 1989, 27, 327-334.

Judson, Philip N.  Industrial Collaboration in Computer Aided Synthesis Design – LHASA UK.  Kemia-Kemi, 1985, 12(2), 150-152.

Elvidge, John A.; Judson, Philip N.; Percival, Albert; Shah, Raksha. Preparation of Some Highly Polarised Ethenes by the Addition of Amines to Suitable Carbonitriles.  Journal of the Chemical Society, Perkin Transactions I, 1983, 1741-1744.

Judson, P. N.  Salts of Tricyanomethane and Related Compounds, and Derived Heterocycles.  PhD Thesis, University of Surrey, October 1977.

Judson, P. N.; Leake, R. A. G.;Smith,  D. W.   Stirrer. Brit.  Appl.  GB 2 131 311 A.

Rowson, G. P.; Percival, A.; Judson, P. N.  Fungicidal Cyanopropenoates and Compositions Containing Them.  Eur.  Appl. EP 88 545, 14th September 1983, Brit. Appl.  82/6480, 5th March 1982.

Judson, P. N.; White, C. R. H.  Fungicidal and Herbicidal Compositions, Certain Cyanomethane and Cyanoethane Derivatives, Being Active Agents Thereof, the Preparation of these Derivatives and Methods for Combating Fungi and Weeds.  Eur.  Pat. Appl.  EP 10 396, 30th April 1980, Brit.  Appl.  78/41689, 24th October 1978.

Percival, A.; Judson, P. N.  Herbicidal Composition Containing a Substituted Pyrazolopyrimidine.  Austrian Pat.  354 186, 27th December 1979, Brit.  Appl.  77/6893, 27th September 1977.

Judson, P. N.  Vapour Condensers.  Brit. Pat.  1588119/1977, Brit.  Appl. 76/52244, (equivalent patents also in Germany and USA).

Percival, A.; Judson, P. N.  Substituted Pyrazolopyrimidines.  Ger. Offen.  2 720 442, 8th December 1977, Brit.  Appl.  76/20147, 15th May 1976.

Judson, P. N.; Saggers, D. T.  Fungicidal Compositions Containing Tetracyanocyclohexenes.  Ger.  Offen. 2 101 789, 29th July 1971, Brit. Appl.  20th January 1970.